Search results for "biosynthesis [Membrane Proteins]"

Maximizing Polyphenol Content to Uncork the Relationship Between Wine and Cancer

2019

Studies have revealed conflicting results regarding the risk of cancer from alcohol consumption. Furthermore, some studies have suggested that wine may have benefits that separate it from other alcoholic beverages. As wine contains a significant amount of chemicals, specifically polyphenols like anthocyanins and proanthocyanidins (PA), that can affect cellular function and promote health, this hypothesis is reasonably supported by recent research. Polyphenols promote several anticancer cellular pathways, including xenobiotic metabolism, support of innate antioxidant production, and stimulation of phase I and II detoxification of carcinogens. However, the multitude of growing and production …

Biosynthesis of heterocycles: From isolation to gene cluster

2015

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification. Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance. Explains the role of natural products in chemistry and their formation. Discusses gene cluster identification and the use of biogenetic engin…

Novel [1,2,3]triazolo[1,5-a]pyridine derivatives are trypanocidal by sterol biosynthesis pathway alteration.

2019

Aim: To study a new series of [1,2,3]triazolo[1,5-α]pyridine derivatives as trypanocidal agents because current antichagasic pharmacologic therapy is only partially effective. Materials & methods: The effect of the series upon Trypanosoma cruzi epimastigotes and murine macrophages viability, cell cycle, cell death and on the metabolites of the sterol biosynthesis pathway was measured; also, docking in 14α-demethylase was analyzed. Results: Compound 16 inhibits 14α-demethylase producing an imbalance in the cholesterol/ergosterol synthesis pathway, as suggested by a metabolic control and theoretical docking analysis. Consequently, it prevented cell proliferation, stopping the cellular cy…

AICA-ribosiduria due to ATIC deficiency: Delineation of the phenotype with three novel cases, and long-term update on the first case.

2020

5-Amino-4-imidazolecarboxamide-ribosiduria (AICA)-ribosiduria is an exceedingly rare autosomal recessive condition resulting from the disruption of the bifunctional purine biosynthesis protein PURH (ATIC), which catalyzes the last two steps of de novo purine synthesis. It is characterized biochemically by the accumulation of AICA-riboside in urine. AICA-ribosiduria had been reported in only one individual, 15 years ago. In this article, we report three novel cases of AICA-ribosiduria from two independent families, with two novel pathogenic variants in ATIC. We also provide a clinical update on the first patient. Based on the phenotypic features shared by these four patients, we define AICA-…

Regulation of the biosynthesis of the dalbavancin precursor A40926

2008

THE SMALL PROTEIN SCO2038 CONTROLS TRYPTOPHAN BIOSYNTHESIS AND DIFFERENTIATION IN STREPTOMYCES COELICOLOR

The cellular regulatory factors comprise regulatory proteins, small RNA and small proteins. It is known that the product of small orfs (smorfs) can regulate the translation of downstream elements and also can encode functional peptides involved in the regulation of specific pathways (Ladoukakis E. et al.,2011). In particular, in the model streptomycete Sfreptomyces coelicolor, smorfs (about 100-300 nucleotides) were identified in some amino acid biosynthetic gene clusters such as in the tryptophan trpCXBA locus (Limauro D. et al., I 990; Hu DS. et al., 1999). In S. coelicolor the molecular mechanisms that regulate tryptophan (Trp) biosynthesis are poorly understood and, unlike the trp opero…

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low…

2014

SPE IPM UB; International audience; : The peroxisomal 3-ketoacyl-CoA thiolase B (ThB) catalyzes the thiolytic cleavage of straight chain 3-ketoacyl-CoAs. Up to now, the ability of ThB to interfere with lipid metabolism was studied in mice fed a routinely laboratory chow enriched or not with the synthetic agonist Wy14,643, a pharmacological activator of the nuclear hormone receptor PPARα. The aim of the present study was therefore to determine whether ThB could play a role in obesity and lipid metabolism when mice are chronically fed a synthetic High Fat Diet (HFD) or a Low Fat Diet (LFD) as a control diet. To investigate this possibility, wild-type (WT) mice and mice deficient for Thb (Thb(…